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The statements made here are backed by scientific research.  However, it must be remembered that many of the following statements do not have FDA approval, nor do they necessarily have the support of a consensus of physicians. 

DHEA
THYROID

ESTROGEN

PROGESTERONE

TESTOSTERONE
              

Human Growth Hormone Replacement Therapy (not prescribed due to Federal law, but interesting).

            Rejuvenates every cell in the body
            Aids in fat loss and muscle gain                         
            Helps the body heal and restore itself
            Strengthens bones 
            Improves sense of well being and sexuality

Research article HGH and Body Composition
Research Article HGH and Weight in Postmenopausal Women
Research Article HGH Deficiency and Replacement
Research Article Start HGH Therapy?

In 1994, the FDA authorized the use of Human Growth Hormone for adults. For the first time, adults are now able to have their age-related deficiency in this critical hormone replaced safely with natural, pharmaceutically produced Human Growth Hormone. The results of HGH replacement are astounding. This is as big a discovery in medicine as antibiotics or the X-ray machine.
Aging can now be delayed and even reversed. Studies have shown that Biomarkers of Aging (strength, reaction time, skin elasticity, vital capacity, concentration, memory, bone density, visual accommodation, hearing, tactile sense, and others) can be reversed 10-20 years. Patients experience 1% gain in lean muscle mass per month and 2% loss of body fat per month. Skin wrinkles and age spots disappear. "It's like plastic surgery from the inside-out". Sexual vitality returns. We anticipate that with HGH replacement along with other indicated hormone replacement including nutrition and exercise, that we can now expect to live to the age of 125 in excellent health.
EFFECT OF HGH DEFICIENCY:
EFFECT OF HGH REPLACEMENT:
Increased Cardiovascular Deaths
Increased Cardiac Function
Abnormal Body Fat & Distribution
Increased Lean Body Mass & Decreased Abdominal Fat Even Without Exercise
Dehydration
Improved Fluid Balance
Reduced Bone Density
Reversal of Osteoporosis
Impaired Physical Performance
Improved Exercise Capacity
Chronic fatigue, Depression
Sense of Well Being
Social Isolation & Withdrawal
Social Interaction & Engagement
Insomnia & Poor Quality Sleep
Restorative Sleep
Skin Thinning & Reduced Healing
Skin Rejuvenation & Rapid Wound Healing
Wrinkles & "Drooping Face"
"Plastic Surgery from the Inside-Out"
Chronic Lung Disorders
Improved Lung Function
Neurocognitive Decline & Senility
Improved Memory, Alertness, and Concentration Span
Decreased Immunity & Increased Susceptibility to Infections
Improved Immunity with More Natural Killer T-4 Cells
Vital Organ Shrinkage & Declining Function
Vital Organ Regrowth & Improved Function

    DHEA      

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                     Can help lipid balance
                     Improves cardiac function
                     Improves blood sugar metabolism and Diabetes
                     Can help with arthritic pain
                     Improves mental acuity

        Research Article DHEA and Body Composition
       
Research Article Loss of Muscle and Hormones with Aging
       
Research Article DHEA and Female Sexuality
       
Research Article DHEA and Remedial Potential

DHEA can be bought over the counter, or more refined products on prescription.  I prefer the prescription product and their sublingual application to the oral tablets.  I can explain this further when we discuss it.  However, the over the counter DHEA is fairly less expensive and readily available.  The prescription sub-lingual may be be better, but the OTC is not bad.  DHEA is produced by the adrenal glands. It begins to drop when we are thirty years old and declines linearly until we die. In fact, death ensues as soon as the DHEA levels hit zero. Some people, therefore, use DHEA levels as a biomarker for aging. DHEA plays a critical role in lowering our cholesterol, keeping our hearts healthy, minimizing fat deposition, preventing the development of diabetes, arthritis, and senility.  Since DHEA is androgizing I go staright to the wanted effect and usually will prescribe bio-identicle testosterone if the DHEA is low.  Of course, I must first verify that the serum testosterone is low.  The effect of DHEA is more profound among women than men.  If you decide to use it on your own without a prescription you should have your blood level checked to see if you're too high or too low.

 

THYROID 

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                    Controls Metabolism
                    Can help with weight management
                    Improves heart and vascular health
                    Renews energy
                    Aids concentration
                    Regulates body temperature

Thyroid hormone is essential for life. Proper thyroid levels are needed for optimal functioning. T3  is the most active hormone available to the cells in our body. Conventional therapy quite often fails to take this into consideration when replacement therapy is given. Synthetic T4 is the usual replacement hormone used, and this can give the hoped for effects. However, in too many instances it doesn't perform as advertised, and the addition of T3 is needed. This can be tested for in my clinic.  In addition, measuring the basal body temperature, which is an indicator of whether we are hypothyroid, can reveal the presence of Wilson's Syndrome, a condition where one always feels cold (and which can be present with the common thyroid tests still being normal).  http://wilsonssyndrome.com At times, replacement of human growth hormone or testosterone to more youthful levels creates a greater need for thyroid hormone. In these cases, the addition of thyroid hormone to our regimen can make a considerable difference.
Iodine is a main ingredient in thyroid hormone, and seafood products are an excellent source for this.  Supplemental selenium can help the body to naturally convert T4 into T3. Thyroid preparations are best take on an empty stomach.

               

ESTROGEN

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Relieves menopausal symptoms
Improves female life expectancy
Protects against Alzheimer's Disease
Improves mood
Prevents Osteoporosis
Prevents Colon Cancer
Improves skin quality and sexual function

Research Article Estrogen/Progesterone and the Heart
Research Article Estrogen and Colon Cancer
Research Article Hormones and Vascular Health
Research Article Hormones in Women Over 40
Research Article Estrogen and Alzheimer's
Research Article Estrogen May Prevent Alzheimer's
Research Article Hormones and Breast Cancer Prevention? (It worked for the rats)
Rebuttal to PREMPRO Study

Estrogen is an essential sex hormone that declines abruptly in women during their menopause. When women do not initiate a prompt estrogen replacement program at the time of menopause, they undergo accelerated aging manifested by: osteoporosis, senility, heart disease, loss of muscle mass, loss of skin elasticity and thickness, atrophy of the female genitalia, and depression.

Estrogen replacement therapy significantly delays or prevents this accelerated aging process seen in women following menopause. In fact, women who take estrogen replacement have half the degenerative diseases of women who do not take estrogen replacement and live an average of 3.5 years longer. What is even more amazing, is that these positive statistics are with those patients on Premarin (non-human estrogen taken from the urine of pregnant horses). The use of more natural estrogen replacement in the form of topical creams, patches or under the tongue drops are a far superior way to go.

Another Alternative View of Estrogen & Progesterone  I do not agree with all of the statements made in this two part article, but it is a wealth of information (most of which I consider to be factual).  The author does seem to have an agenda, and it appears to center around the belief that female medicine is a male conspiracy.  The only conspiracies that I'm aware of are 1)the corporate greed of the insurance and pharmaceutical industries, 2) the socialistic government regulators who know better than you and your doctor what's good for you, and 3) the media who will fill you full of half truths for advertising revenue. To sort out what I consider to be the answer to the issues raised in the article we can discuss any questions you have in my office. (Write down your questions)

What estrogens do I use?

I try to avoid most commercial preparations due to their pitfalls (as described in the above "alternative view" link).  Not only do they tends to fail in optimizing the potential anti-aging effects of hormone replacement therapy, but they probably add to certain risk factors themselves.  When I prescribe estrogen I tend to suggest a more European blend called Bi-est.  Bi-est is a blend of estradiol (which provides most of the menopausal relief and post-menopausal anti-aging) and estriol (which seems to protect against the small breast cancer potential of estradiol).  Almost all commercial preparations are either straight estradiol or a blend of 50-some horse estrogens (Premarin or Prempro which is even worse).  Bi-est is usually paid for by insurance companies, and it is relatively inexpensive. 
  
Estriol and Breast Cancer Prevention
Estriol and Breast Cancer
Estriol Experiments

        PROGESTERONE     

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                     Natural anti-depressant and tranquilizer
            Boosts thyroid action
            Aids in the metabolism of body fat
            Helps prevent Osteoporosis

            Research Article Estrogen/Progesterone and the Heart
           
Research Article Progesterone and Spatial Memory
           
Research Article Hormones and Breast Cancer 
            Prevention? (It worked for the rats)    

Progesterone is also a female sex hormone that keeps estrogen in balance and is therefore absolutely necessary in the female hormone replacement program regardless of whether the female has a uterus or not. This concept is not understood by some physicians and this has lead to an increase in cancers of the uterus and breast in women on estrogen replacement, alone. Progesterone has powerful anti-cancer properties. In addition, Progesterone facilitates the action of other hormones such as thyroid, testosterone, and endorphins. Synthetic progesterones (progestins) such as Provera lack many of the beneficial properties of Progesterone and in fact actually serve to increase LDL "the bad form of cholesterol". Provera also does not have the beneficial effect that Progesterone has in increasing bone mass, reversing osteoporosis, and burning fat. 

See the link at the end of above Estrogen section for another view on estrogen and progesterone.

 

              

        TESTOSTERONE        

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                Boosts male and female libido      
                Encourages heart health 
                Fights fat
                Increases muscle mass and strength

                Research Article Testosterone for Older Men?
               
Research Article Testosterone in Women
               
Research Article Testosterone after Hysterectomy
               
Research Article Is Estrogen Enough?

Both men and women need testosterone for optimal health. Testosterone is needed for libido, muscle strength, leanness, and sense of well being. Menopausal women have low to non-detectable testosterone levels with resultant loss of libido and increase in body fat. Return of libido and improved mood return within days of testosterone replacement by transdermal cream or drops under the tongue.. Regrowth of muscle and bone occurs within months and is facilitated by a weight resistance training program.

The testosterone level in males peaks at age 17 and declines 1% per year thereafter. A middle-aged male can therefore have a testosterone level 40% below his peak in young adulthood. This problem can be compounded by the increased production of sex binding globulins, which make the lowered testosterone that is present even less effective. Loss of testosterone in males leads to atherosclerosis and heart attacks, obesity, fatigue, depression, and anxiety. These symptoms come on long before the male loses his sex drive or becomes impotent. There is speculation that testosterone replacement therapy in males causes prostate cancer or prostate enlargement. There is no proof of this. In fact, some Urologist-Oncologists say that testosterone may decrease the incidence of prostatic hypertrophy and prostate cancer. 
Testosterone References:

Carter HB, Pearson JD, Metter EJ, Chan DW, Andres R, Fozard JL, Rosner W, Walsh PC. Prostate 1995 Jul;27(1):25-31. Longitudinal evaluation of serum androgen levels in men with and without prostate cancer.

There was no correlation of serum testosterone or free testosterone with prostate cancer
Cooper CS, MacIndoe JH, Perry PJ, Yates WR, Williams RD. J Urol 1996 Aug;156(2 Pt 1):438-41; discussion 441-2 The effect of exogenous testosterone on total and free prostate specific antigen levels in healthy young men.

There was no increase in PSA when supplemental testosterone was used

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