The role of oxidative stress in the pathogenesis of age-related macular degeneration.
Beatty S, Koh H, Phil M, Henson D, Boulton M.Surv Ophthalmol. 2000
Academic Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester,
Age-related macular degeneration (AMD) is the leading cause of blind registration
in the developed world, and yet its pathogenesis remains poorly understood. Oxidative stress, which refers to cellular damage
caused by reactive oxygen intermediates (ROI), has been implicated in many disease processes, especially age-related disorders.
ROIs include free radicals, hydrogen peroxide, and singlet oxygen, and they are often the byproducts of oxygen metabolism.
The retina is particularly susceptible to oxidative stress because of its high consumption of oxygen, its high proportion
of polyunsaturated fatty acids, and its exposure to visible light. In vitro studies
have consistently shown that photochemical retinal injury is attributable to oxidative stress and that the antioxidant vitamins
A, C, and E protect against this type of injury.Furthermore, there is strong evidence suggesting that lipofuscin is
derived, at least in part, from oxidatively damaged photoreceptor outer segments and that it is itself a photoreactive substance.
However, the relationships between dietary and serum levels of the antioxidant vitamins and age-related macular disease are
less clear, althougha protective effect of high plasma concentrations of alpha-tocopherol
(Vitamin E) has been convincingly demonstrated.Macular pigment is also believed to limit retinal oxidative
damage by absorbing incoming blue light and/or quenching ROIs. Many putative risk-factors for AMD have been linked to a lack
of macular pigment, including female gender, lens density, tobacco use, light iris color, and reduced visual sensitivity.
Moreover, the Eye Disease Case-Control Study found that high plasma levels of lutein and zeaxanthin were associated with reduced
risk of neovascular AMD. The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven.
With a view to reducing oxidative damage, the effect of nutritional antioxidant supplements on the onset and natural course
of age-related macular disease is currently being evaluated.
Omega-3, as found in Fish Oil, has
also been associated with preventing and helping Macular Degeneration. If your serious about this then I would take
2000-3000 mg of omega-3 daily. This is not fish oil but omega-3 milligrams your counting. You can calculate the
omega-3 content of fish oil by simply adding the DHA plus the EPA listed on the bottle.
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